Overview
This guide will show a description of how to unlock every achievement in the game. The achievements are placed by ID.
Rebirth Achievements (Part 1)
Magdalene – Have 7 or more Red Heart containers at one time
Cain – Hold 55 coins at one time
Judas – Defeat Satan
The Womb – Defeat Mom
The Harbringers – Defeat Mom
A Cube of Meat – Defeat Mom
The Book of Revelations – Defeat a Harbinger
A Noose – Defeat Mom’s Heart 3 times
The Nail – Complete the Boss Rush as Azazel
A Quarter – Defeat Mom’s Heart 8 times
A Fetus in a Jar – Defeat Mom’s Heart 9 times
A Small Rock – Destroy 100 Tinted Rocks
Monstro’s Tooth – Beat chapter 1
Lil’ Chubby – Beat chapter 2
Loki’s Horns – Defeat Lokii
Something From The Future – Beat Basem*nt 40 times
Something Cute – Beat chapter 2 30 times
Something Sticky – Beat chapter 3 20 times
A Bandage – Make a Super Bandage Girl by picking up 4 Balls of Bandages in one run
A Cross – Defeat Isaac as Magdalene
A Bag of Pennies – Defeat Isaac as Cain
The Book of Sin – Defeat all 7 deadly sins
Little Gish – Defeat Gish
Little Steven – Defeat Steven
Little C.H.A.D. – Defeat C.H.A.D.
A Gamekid – Visit 10 Arcades
A Halo – Defeat Mom, Mom’s Heart or It Lives using The Bible
Mr. Mega – Destroy 10 Tinted Rocks
The D6 – Defeat Isaac as ???
The Scissors – Die 100 times
The Parasite – Pick up any 2 of the following items in a single run: Bob’s Rotten Head, Dead Cat, Cricket’s Head, Tammy’s Head
??? – Defeat Mom’s Heart 10 times
Everything Is Terrible!!! – Defeat Mom’s Heart 5 times
It Lives! – Defeat Mom’s Heart 11 times
Mom’s Contact – Obtain three Yes Mother? items in one run
The Necronomicon – Use XIII – Death 4 times
Basem*nt Boy – Beat chapter 1 without taking damage
Spelunker Boy – Beat chapter 2 without taking damage
Dark Boy – Beat chapter 3 without taking damage
Mama’s Boy – Beat chapter 4 without taking damage
Golden God! – Defeat ??? and The Lamb
Eve – Don’t pick up any hearts for 2 floors in a row
Mom’s Knife – Defeat Satan as Isaac
The Razor – Defeat Satan as Eve
Guardian Angel – Defeat Satan as Magdalene
A Bag of Bombs – Defeat Satan as Cain
Demon Baby – Defeat The Lamb as Azazel
Forget Me Now – Defeat Satan as ???
The D20 – Defeat ??? as Isaac
Celtic Cross – Defeat ??? as Magdalene
Abel – Defeat The Lamb as Cain
Curved Horn – Defeat The Lamb as Judas
Sacrificial Dagger – Defeat ??? as Eve
Bloody Lust – Defeat Isaac as Samson
Blood Penny – Defeat ??? as Samson
Blood Rights – Defeat Satan as Samson
The Polaroid – Defeat Isaac 5 times
Dad’s Key – Pick up both Key Pieces from the Angels in one run
Blue Candle – Donate 900 coins to the Donation Machine
Burnt Penny – Complete Beans! (challenge #13)
Lucky Toe – Blow up 20 Shopkeepers
Epic Fetus – Complete The Family Man (challenge #19)
SMB Super Fan – Complete It’s in the Cards (challenge #14)
Counterfeit Coin – Play Shell Game 100 times
Guppy’s Hairball – Become Guppy
A Forgotten Horseman – Take 10 items from Angel Rooms
Samson – Complete 2 floors in a row without taking damage
Something Icky – Defeat Isaac 10 times
!Platinum God! – Collect all non – DLC items in the game, unlock all of the secrets and endings minus The Lost and his 6 unlockable items
Isaac’s Head – Complete the Boss Rush as Isaac
Maggy’s Faith – Defeat The Lamb as Magdalene
Judas’ Tongue – Defeat Satan as Judas
???’s Soul – Defeat The Lamb as ???
Samson’s Lock – Defeat The Lamb as Samson
Cain’s Eye – Defeat ??? as Cain
Eve’s Bird Foot – Defeat Isaac as Eve
The Left Hand – Defeat Ultra Pride as any character, or ??? as Judas
The Negative – Defeat Satan 5 times
Azazel – Make 3 deals with the Devil in one run
Lazarus – Have 4 or more Soul Hearts at one time
Eden – Complete chapter 4
The Lost – Die in a Sacrifice Room while holding Missing Poster
Dead Boy – Complete chapter 6 without taking damage
The Real Platinum God – Collect every non-DLC item, unlock every secret and ending.
Lucky Rock – Destroy 100 rocks
The Cellar – Beat all The Basem*nt bosses
The Catacombs – Beat all The Catacombs bosses
The Necropolis – Beat all The Depths bosses
Rune of Hagalaz – Complete Pitch Black (challenge #1)
Rune of Jera – Complete High Brow (challenge #2)
Rune of Ehwaz – Complete Head Trauma (challenge #3)
Rune of Dagaz – Complete Darkness Falls (challenge #4)
Rune of Ansuz – Complete The Tank (challenge #5)
Rune of Perthro – Complete Solar System (challenge #6)
Rune of Berkano – Complete Purist (challenge #20)
Rune of Algiz – Complete Cat Got Your Tongue (challenge #8)
Chaos Card – Complete Demo Man (challenge #9)
Credit Card – Complete Cursed (challenge #10)
Rules Card – Complete Glass Cannon (challenge #11)
Card Against Humanity – Complete When Life Gives You Lemons (challenge #12)
Swallowed Penny – Complete Slow Roll (challenge #15)
Robo-Baby 2.0 – Complete Computer Savvy (challenge #16)
Death’s Touch – Complete Waka Waka (challenge #17)
Technology .5 – Complete The Host (challenge #18)
Missing No. – Complete the Boss Rush as Lazarus
Isaac’s Tears – Defeat Isaac as Isaac
Guillotine – Defeat Isaac as Judas
Judas’ Shadow – Complete the Boss Rush as Judas
Maggy’s Bow – Complete the Boss Rush as Magdalene
Cain’s Other Eye – Complete the Boss Rush as Cain
Black Lipstick – Defeat The Lamb as Eve
Eve’s Mascara – Complete the Boss Rush as Eve
Fate – Defeat ??? as ???
???’s Only Friend – Complete the Boss Rush as ???
Samson’s Chains – Complete the Boss Rush as Samson
Lazarus’ Rags – Defeat Isaac as Lazarus
Broken Ankh – Defeat Satan as Lazarus
Store Credit – Defeat ??? as Lazarus
Pandora’s Box – Defeat The Lamb as Lazarus
Suicide King – Complete Suicide King (challenge #7)
Blank Card – Defeat Isaac as Eden
Book of Secrets – Defeat Satan as Eden
Mysterious Paper – Beat ??? as Eden
Mystery Sack – Defeat The Lamb as Eden
Undefined – Complete the Boss Rush as Eden
Satanic Bible – Defeat Isaac as Azazel
Daemon’s Tail – Defeat Satan as Azazel
Abaddon – Defeat ??? as Azazel
Isaac’s Heart – Defeat Isaac as The Lost
The Mind – Defeat Satan as The Lost
The Body – Defeat ??? as The Lost
The Soul – Defeat The Lamb as The Lost
The D100 – Complete the Boss Rush as The Lost
Blue Map – Donate 10 coins to the Donation Machine
There’s Options – Donate 50 coins to the Donation Machine
Black Candle – Donate 150 coins to the Donation Machine
Red Candle – Donate 400 coins to the Donation Machine
Stop Watch – Donate 999 coins to the Donation Machine
Wire Coat Hanger – Defeat Mom’s Heart 4 times
Ipecac – Defeat Mom’s Heart 6 times
Experimental Treatment – Defeat Mom’s Heart 7 times
Krampus – Take 20 items from Devil Rooms
Head of Krampus – Defeat Krampus
Super Meat Boy – Make a Super Meat Boy by picking up Cube of Meat 4 times in one run
Butter Bean – Destroy 100 poops
Little Baggy – Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball
Blood Bag – Use the Blood Donation Machine 30 times
The D4 – Blow up 30 Arcade machines
Missing Poster – Defeat The Lamb as Isaac
Rubber Cement – Defeat Mom’s Heart 2 times
Store Upgrade lv.1 – Donate 20 coins to the Donation Machine
Store Upgrade lv.2 – Donate 100 coins to the Donation Machine
Store Upgrade lv.3 – Donate 200 coins to the Donation Machine
Store Upgrade lv.4 – Donate 600 coins to the Donation Machine
Angels – Complete chapter 6
Godhead – Earn all 12 completion marks on Hard mode as The Lost
Darkness Falls – Defeat Mom’s Heart, Satan and ??? as Eve
The Tank – Have 7 or more Red Heart containers at one time
Solar System – Defeat Mom’s Heart 3 times
Suicide King – Defeat Mom’s Heart 11 times
Cat Got Your Tongue – Become Guppy
Demo Man – Defeat Mom’s Heart 9 times
Cursed! – Have 7 or more Red Heart Containers at one time
Glass Cannon – Beat The Family Man (challenge #19) and defeat Lokii
The Family Man – Pick up both Key Pieces from the Angels in one run
Purist – Defeat Mom
Rebirth Achievement (Part 2)
Lost Baby – Defeat Mom’s Heart on Hard mode as Isaac
Cute Baby – Defeat Mom’s Heart on Hard mode as Magdalene
Crow Baby – Defeat Mom’s Heart on Hard mode as Eve
Shadow Baby – Defeat Mom’s Heart on Hard mode as Judas
Glass Baby – Defeat Mom’s Heart on Hard mode as Cain
Wrapped Baby – Defeat Mom’s Heart on Hard mode as Lazarus
Begotten Baby – Defeat Mom’s Heart on Hard mode as Azazel
Dead Baby – Defeat Mom’s Heart on Hard mode as ???
-0- Baby – Defeat Mom’s Heart on Hard mode as The Lost
Glitch Baby – Defeat Mom’s Heart on Hard mode as Eden
Fighting Baby – Defeat Mom’s Heart on Hard mode as Samson
Lord of The Flies – Become Beelzebub
Afterbirth Achievements
Fart Baby – Defeat Hush as Isaac
Purity – Defeat Hush as Magdalene
D12 – Defeat Hush as Cain
Betrayal – Defeat Hush as Judas
Fate’s Reward – Defeat Hush as ???
Athame – Defeat Hush as Eve
Blind Rage – Defeat Hush as Samson
Maw of the Void – Defeat Hush as Azazel
Empty Vessel – Defeat Hush as Lazarus
Eden’s Blessing – Defeat Hush as Eden
Sworn Protector – Defeat Hush as The Lost
Incubus – Defeat Hush as Lilith
Keeper now holds…A Penny! – Defeat Hush as Keeper
Lil’ Chest – Defeat Ultra Greed as Isaac
Censer – Defeat Ultra Greed as Magdalene
Evil Eye – Defeat Ultra Greed as Cain
My Shadow – Defeat Ultra Greed as Judas
Cracked Dice – Defeat Ultra Greed as ???
Black Feather – Defeat Ultra Greed as Eve
Lusty Blood – Defeat Ultra Greed as Samson
Lilith – Defeat Ultra Greed as Azazel
Key Bum – Defeat Ultra Greed as Lazarus
GB Bug – Defeat Ultra Greed as Eden
Zodiac – Defeat Ultra Greed as The Lost
Box of Friends – Defeat Ultra Greed as Lilith
Rib of Greed – Defeat Ultra Greed as Keeper
Cry Baby – Defeat Mega Satan as Isaac
Red Baby – Defeat Mega Satan as Magdalene
Green Baby – Defeat Mega Satan as Cain
Brown Baby – Defeat Mega Satan as Judas
Blue Baby – Defeat Mega Satan as ???
Lil’ Baby – Defeat Mega Satan as Eve
Rage Baby – Defeat Mega Satan as Samson
Black Baby – Defeat Mega Satan as Azazel
Long Baby – Defeat Mega Satan as Lazarus
Yellow Baby – Defeat Mega Satan as Eden
White Baby – Defeat Mega Satan as The Lost
Big Baby – Defeat Mega Satan as Lilith
Noose Baby – Defeat Mega Satan as Keeper
Rune Bag – Defeat Isaac as Lilith
Cambion Conception – Defeat ??? as Lilith
Serpent’s Kiss – Defeat Satan as Lilith
Succubus – Defeat The Lamb as Lilith
Immaculate Conception – Complete the Boss Rush as Lilith
Goat Head Baby – Defeat Mom’s Heart on Hard mode as Lilith
Gold Heart – Complete XXXXXXXXL (challenge #21)
Get out of Jail Free Card – Complete SPEED! (challenge #22)
Gold Bomb – Complete Blue Bomber (challenge #23)
2 new pills – Complete PAY TO PLAY (challenge #24)
2 new pills (no it’s not a typo) – Complete Have a Heart (challenge #25)
Poker Chip – Complete I RULE! (challenge #26)
Stud Finder – Complete BRAINS! (challenge #27)
D8 – Complete PRIDE DAY! (challenge #28)
Kidney Stone – Complete Onan’s Streak (challenge #29)
Black Rune – Complete The Guardian (challenge #30)
Blue Womb – Defeat Mom’s Heart 10 times
1001% – Unlock all of the secrets and endings, and collect every item in the game
Keeper holds Wooden Nickel – Defeat Isaac as Keeper
Keeper holds Store Key – Defeat Satan as Keeper
Deep Pockets – Defeat ??? as Keeper
Karma – Defeat The Lamb as Keeper
Sticky Nickels – Complete the Boss Rush as Keeper
Super Greed Baby – Defeat Mom’s Heart on Hard mode as Keeper
Lucky Pennies – Donate 1 coin to the Greed Donation Machine
Special Hanging Shopkeepers – Donate 10 coins to the Greed Donation Machine
Wooden Nickel – Donate 30 coins to the Greed Donation Machine
Cain holds Paperclip – Donate 68 coins to the Greed Donation Machine
Everything is Terrible 2!!! – Donate 111 coins to the Greed Donation Machine
Special Shopkeepers – Donate 234 coins to the Greed Donation Machine
Eve now holds Razor Blade – Donate 439 coins to the Greed Donation Machine
Store Key – Donate 666 coins to the Greed Donation Machine
Lost holds Holy Mantle – Donate 879 coins to the Greed Donation Machine
Keeper – Donate 1000 coins to the Greed Donation Machine
Hive Baby – Earn all Hard mode completion marks as ???
Buddy Baby – Earn all Hard mode completion marks as Isaac
Colorful Baby – Earn all Hard mode completion marks as Magdalene
♥♥♥♥♥ Baby – Earn all Hard mode completion marks as Eve
Cracked Baby – Earn all Hard mode completion marks as Eden
Dripping Baby – Earn all Hard mode completion marks as Lazarus
Blinding Baby – Use Blank Card while holding XIX – The Sun
Sucky Baby – Earn all Hard mode completion marks as Azazel
Dark Baby – Earn all Hard mode completion marks as Lilith
Picky Baby – Earn all Hard mode completion marks as Cain
Revenge Baby – Earn all Hard mode completion marks as Samson
Belial Baby – Earn all Hard mode completion marks as Judas
Sale Baby – Earn all Hard mode completion marks as Keeper
XXXXXXXXL – Defeat Mom
SPEED! – Defeat Mom
Blue Bomber – Destroy 10 Tinted Rocks and defeat Mom’s Heart 11 times
PAY TO PLAY – Defeat Isaac as Cain
Have a Heart – Defeat Mom
I RULE! – Defeat Mega Satan
BRAINS! – Defeat Isaac 5 times
PRIDE DAY! – Defeat Mom
Onan’s Streak – Defeat Mom
The Guardian – Defeat Mom
Generosity – Donate 999 coins to the Greed Donation Machine
Mega – Defeat Mega Satan as every character
Afterbirth+ Achievements
Backasswards – Defeat Mega Satan
Aprils fool – Defeat Mom
Pokey Mans – Defeat Mom’s Heart 11 times
Ultra Hard – Defeat Mega Satan
PONG – Defeat Isaac 5 times
D Infinity – Defeat Delirium as Isaac
Eucharist – Defeat Delirium as Magdalene
Silver Dollar – Defeat Delirium as Cain
Shade – Defeat Delirium as Judas
King Baby – Defeat Delirium as ???
Bloody Crown – Defeat Delirium as Samson
Dull Razor – Defeat Delirium as Eve
Eden’s Soul – Defeat Delirium as Eden
Dark Prince’s Crown – Defeat Delirium as Azazel
Compound Fracture – Defeat Delirium as Lazarus
Euthanasia – Defeat Delirium as Lilith
Holy Card – Defeat Delirium as The Lost
Crooked Penny – Defeat Delirium as Keeper
Void – Defeat Delirium as Apollyon
D1 – Defeat Ultra Greedier as Isaac
Glyph of Balance – Defeat Ultra Greedier as Magdalene
Sack of Sacks – Defeat Ultra Greedier as Cain
Eye of Belial – Defeat Ultra Greedier as Judas
Meconium – Defeat Ultra Greedier as ???
Stem Cell – Defeat Ultra Greedier as Samson
Crow Heart – Defeat Ultra Greedier as Eve
Metronome – Defeat Ultra Greedier as Eden
Bat Wing – Defeat Ultra Greedier as Azazel
Plan C – Defeat Ultra Greedier as Lazarus
Duality – Defeat Ultra Greedier as Lilith
Dad’s Lost Coin – Defeat Ultra Greedier as The Lost
Eye of Greed – Defeat Ultra Greedier as Keeper
Black Rune – Defeat Ultra Greedier as Apollyon
Locust of Wrath – Defeat Isaac as Apollyon
Locust of Pestilence – Defeat Satan as Apollyon
Locust of Famine – Defeat ??? as Apollyon
Locust of Death – Defeat The Lamb as Apollyon
Locust of Conquest – Complete the Boss Rush as Apollyon
Hushy – Defeat Hush as Apollyon
Brown Nugget – Defeat Ultra Greed as Apollyon
Mort Baby – Defeat Mega Satan as Apollyon
Smelter – Defeat Mom’s Heart or It Lives! on Hard mode as Apollyon
Apollyon Baby – Earn all Hard mode completion marks as Apollyon
New Area – Defeat Hush
Once More with Feeling! – Complete a Victory Lap, defeating The Lamb
Hat Trick – Get a 3-win streak
5 Nights at Mom’s – Get a 3 win-streak using a different character each time
Sin Collector – Collect every entry in the Bestiary
Dedication – Participate in 31 daily challenges
ZIP! – Defeat The Lamb in under 20 minutes
It’s the Key – Defeat The Lamb without taking hearts, coins, and bombs through an entire run
The Resetter! – Reset 7 times in a row
Living on the edge – Complete a Chapter (floors I and II) after The Basem*nt, start-to-finish, with only half a heart of health (can use The Lost)
U Broke It! – Obtain 50 items on a run
Laz Bleeds More! – Complete Backasswards (challenge #31)
Maggy Now Holds a Pill! – Complete Aprils Fool (challenge #32)
Charged Key – Complete Pokey Mans (challenge #33)
Samson Feels Healthy – Complete Ultra Hard (challenge #34)
Greed’s Gullet – Complete Pong (challenge #35)
The Marathon – Get a 5-win streak in the daily challenges (You must have a score of above 0 on the score screen)
RERUN – Complete 3 Victory Laps and start a 4th
Delirious – Defeat Delirium
1,000,000% – Collect every item in the game, unlock all secrets and endings, and complete the bestiary
Apollyon – Defeat Mega Satan
Greedier! – Donate 500 coins to the Greed Donation Machine
Burning Basem*nt – Defeat Mom’s Heart 11 times
Flooded Caves – Defeat It Lives 16 times
Dank Depths – Defeat It Lives 21 times
Scarred Womb – Defeat It Lives 30 times
Something wicked this way comes! – Defeat ??? as 3 different characters
Something wicked this way comes+! – Defeat ??? as 6 different characters
The gate is open! – Defeat The Lamb
Black Hole – Defeat 20 portals
Mystery Gift – Destroy 500 rocks
Sprinkler – Beat chapter 1 without taking damage
Angry Fly – Become Beelzebub
Bozo – Destroy 5 rainbow poops
Broken Modem – Complete 7 daily challenges (by touching the trophy at the end)
Buddy in a Box – Pick up 5 familiars in a single run
Fast Bombs – Defeat Little Horn 20 times
Lil Delirium – Defeat Delirium for the 1st time
Hairpin – Recharge using Lil’ Batteries 20 times
Wooden Cross – Sleep in a bed
Butter! – Complete 2 Victory Laps and start a 3rd
Huge Growth – Increase in size 5 times in a single run. Sources of increased size include “One Makes you Larger” pills, XI – Strength, and Magic Mushroom
Ancient Recall – Use cards and runes 20 times
Era Walk – Have both the Broken Watch and the Stop Watch in your collection
Coupon – Purchase from Shops, Devil deals or Black Markets 50 times
Telekinesis – Beat chapter 2 without taking damage
Moving Box – Use Pandora’s Box in Dark Room
Jumper Cables – Pick up any 3 of the following items/trinkets in a single run: Battery Pack, AAA Battery, Watch Battery
Leprosy – Beat chapter 3 without taking damage
Technology Zero – Pick up two technology items in one run
Filigree Feather – Acquire both key pieces
Mr. ME! – Open 20 Locked Chests
7 Seals – Defeat all 5 Harbingers
Angelic Prism – Defeat an Angel 10 times
Pop! – Beat chapter 4 without taking damage
Door Stop – Blow up doors and Secret Room walls 50 times
Death’s List – Take 25 Devil deals
Haemolacria – Acquire Blood Clot 10 times
Lachryphagy – Collect 10 “tears up” items or pills in one run
Schoolbag – Enter every Shop from chapter 1 through chapter 3 in one run
Trisagion – Take 25 items from Angel Rooms
Extension Cord – Have The Battery, 9 Volt, and Car Battery in your collection
Flat Stone – Acquire Rubber Cement 5 times
Sacrificial Altar – Take 50 Devil deals
Lil Spewer – Die to your own explosion from Ipecac, Bob’s Rotten Head, or Horf! pill
Blanket – Sleep in 10 beds
Marbles – Use 5 Gulp! pills in one run (Placebo uses count)
Mystery Egg – Spawn three charmed enemies in the same room
Rotten Penny – Have 20 Blue Flies at the same time
Baby – Bender – Use I – The Magician or Telepathy for Dummies while already having homing tears
The Forgotten – It’s complicated, but just get both mom’s shovel parts, go to an empty room in Dark Room.
Bone Heart – Unlock The Forgotten
Marrow – Defeat Mom’s Heart or It Lives! on Hard mode as The Forgotten
Slipped Rib – Defeat Isaac as The Forgotten
Pointy Rib – Defeat Satan as The Forgotten
Jaw Bone – Defeat ??? as The Forgotten
Brittle Bones – Defeat The Lamb as The Forgotten
Divorce Papers – Complete the Boss Rush as The Forgotten
Hallowed Ground – Defeat Hush as The Forgotten
Finger Bone – Defeat Ultra Greed as The Forgotten
Dad’s Ring – Defeat Ultra Greedier as The Forgotten
Book of the Dead – Defeat Delirium as The Forgotten
Bone Baby – Earn all Hard mode completion marks as The Forgotten
Bound Baby – Defeat Mega Satan as The Forgotten
Repentance Achievements (Part 1)
Bethany – Defeat Mom’s Heart/It Lives on hard mode as Lazarus Lazarus, without dying at all
Jacob and Esau – Defeat Mother
The Planetarium – Collect three stars items in a single run
A Secret Exit – Defeat Hush 3 times
Forgotten Lullaby – Blow up The Siren’s skull after defeating her
Fruity Plum – Defeat Baby Plum 10 times
Plum Flute – Allow Baby Plum to escape instead of defeating her
Rotten Heart – Enter the Corpse for the first time
Dross – Defeat all bosses in Downpour
Ashpit – Defeat all bosses in Mines
Gehenna – Defeat all bosses in Mausoleum
Red Key – Open the large version of Mom’s Box in Home
Wisp Baby – Defeat Mom’s Heart or It Lives! on Hard mode as Bethany
Book of Virtues – Defeat Isaac as Bethany
Urn of Souls – Defeat Satan as Bethany
Blessed Penny – Defeat ??? as Bethany
Alabaster Box – Defeat The Lamb as Bethany
Beth’s Faith – Complete the Boss Rush as Bethany
Soul Locket – Defeat Ultra Greed as Bethany
Divine Intervention – Defeat Hush as Bethany
Vade Retro – Defeat Ultra Greedier as Bethany
Star of Bethlehem – Defeat Delirium as Bethany
Hope Baby – Earn all Hard mode completion marks as Bethany
Glowing Baby – Defeat Mega Satan as Bethany
Double Baby – Defeat Mom’s Heart or It Lives! on Hard mode as Jacob and Esau
The Stairway – Defeat Isaac as Jacob and Esau
Red Stew – Defeat Satan as Jacob and Esau
Birthright – Defeat ??? as Jacob and Esau
Damocles – Defeat The Lamb as Jacob and Esau
Rock Bottom – Complete Boss Rush as Jacob and Esau
Inner Child – Defeat Ultra Greed as Jacob and Esau
Vanishing Twin – Defeat Hush as Jacob and Esau
Genesis – Defeat Ultra Greedier as Jacob and Esau
Suplex! – Defeat Delirium as Jacob and Esau
Solomon’s Baby – Earn all Hard mode completion marks as Jacob and Esau
Illusion Baby – Defeat Mega Satan as Jacob and Esau
Meat Cleaver – Defeat Mother as Isaac
Options? – Defeat The Beast as Isaac
Yuck Heart – Defeat Mother as Magdalene
Candy Heart – Defeat The Beast as Magdalene
Guppy’s Eye – Defeat Mother as Cain
A Pound of Flesh – Defeat The Beast as Cain
Akeldama – Defeat Mother as Judas
Redemption – Defeat The Beast as Judas
Eternal D6 – Defeat Mother as ???
Montezuma’s Revenge – Defeat The Beast as ???
Bird Cage – Defeat Mother as Eve
Cracked Orb – Defeat The Beast as Eve
Bloody Gust – Defeat Mother as Samson
Empty Heart – Defeat The Beast as Samson
Devil’s Crown – Defeat Mother as Azazel
Lil Abaddon – Defeat The Beast as Azazel
Tinytoma – Defeat Mother as Lazarus
Astral Projection – Defeat The Beast as Lazarus
‘M – Defeat Mother as Eden
Everything Jar – Defeat The Beast as Eden
Lost Soul – Defeat Mother as The Lost
Hungry Soul – Defeat The Beast as The Lost
Blood Puppy – Defeat Mother as Lilith
C Section – Defeat The Beast as Lilith
Keeper’s Sack – Defeat Mother as Keeper
Keeper’s Box – Defeat The Beast as Keeper
Lil Portal – Defeat Mother as Apollyon
Worm Friend – Defeat The Beast as Apollyon
Bone Spurs – Defeat Mother as The Forgotten
Spirit Shackles – Defeat The Beast as The Forgotten
Revelation – Defeat Mother as Bethany
Jar of Wisps – Defeat The Beast as Bethany
Magic Skin – Defeat Mother as Jacob and Esau
Friend Finder – Defeat The Beast as Jacob and Esau
The Broken – Use the Red Key or Cracked Key in Home as Isaac
The Dauntless – Use the Red Key or Cracked Key in Home as Magdalene
The Hoarder – Use the Red Key or Cracked Key in Home as Cain
The Deceiver – Use the Red Key or Cracked Key in Home as Judas
The Soiled – Use the Red Key or Cracked Key in Home as ???
The Curdled – Use the Red Key or Cracked Key in Home as Eve
The Savage – Use the Red Key or Cracked Key in Home as Samson
The Benighted – Use the Red Key or Cracked Key in Home as Azazel
The Enigma – Use the Red Key or Cracked Key in Home as Lazarus
The Capricious – Use the Red Key or Cracked Key in Home as Eden
The Baleful – Use the Red Key or Cracked Key in Home as The Lost
The Harlot – Use the Red Key or Cracked Key in Home as Lilith
The Miser – Use the Red Key or Cracked Key in Home as Keeper
The Empty – Use the Red Key or Cracked Key in Home as Apollyon
The Fettered – Use the Red Key or Cracked Key in Home as The Forgotten
The Zealot – Use the Red Key or Cracked Key in Home as Bethany
The Deserter – Use the Red Key or Cracked Key in Home as Jacob and Esau
Glitched Crown – Defeat The Beast as Tainted Isaac
Belly Jelly – Defeat The Beast as Tainted Magdalene
Blue Key – Defeat The Beast as Tainted Cain
Sanguine Bond – Defeat The Beast as Tainted Judas
The Swarm – Defeat The Beast as Tainted ???
Heartbreak – Defeat The Beast as Tainted Eve
Larynx – Defeat The Beast as Tainted Samson
Azazel’s Rage – Defeat The Beast as Tainted Azazel
Salvation – Defeat The Beast as Tainted Lazarus
TMTRAINER – Defeat The Beast as Tainted Eden
Sacred Orb – Defeat The Beast as Tainted Lost
Twisted Pair – Defeat The Beast as Tainted Lilith
Strawman – Defeat The Beast as Tainted Keeper
Echo Chamber – Defeat The Beast as Tainted Apollyon
Isaac’s Tomb – Defeat The Beast as Tainted Forgotten
Vengeful Spirit – Defeat The Beast as Tainted Bethany
Esau Jr. – Defeat The Beast as Tainted Jacob
Bloody Mary – Defeat Mom’s Heart/It Lives on hard mode as Lazarus, without dying, defeat Mom’s Heart 11 times and unlock Blood Bag
Baptism by Fire – Defeat Satan as Bethany, defeat Mom’s Heart 11 times and unlock Maggy’s Faith
Isaac’s Awakening – Defeat Mother
Seeing Double – Defeat Mother
Pica Run – Defeat Mom’s Heart 11 times and Unlock Marbles
Hot Potato – Use the Red Key or Cracked Key in Home as The Forgotten
Cantripped! – Use the Red Key or Cracked Key in Home as Cain
Red Redemption – Use the Red Key or Cracked Key in Home as Jacob and Esau
DELETE THIS – Use the Red Key or Cracked Key in Home as Eden
Dirty Mind – Complete Scat Man (challenge #36)
Sigil of Baphomet – Complete Bloody Mary (challenge #37)
Purgatory – Complete Baptism by Fire (challenge #38)
Spirit Sword – Complete Isaac’s Awakening (challenge #39)
Broken Glasses – Complete Seeing Double (challenge #40)
Ice Cube – Complete Pica Run (challenge #41)
Charged Penny – Donate to Battery Bums until they pay out with an item 5 times
The Fool – Defeat Ultra Greedier as Tainted Lost
The Magician – Defeat Ultra Greedier as Tainted Judas
The High Priestess – Defeat Ultra Greedier as Tainted Lilith
The Empress – Defeat Ultra Greedier as Tainted Eve
The Emperor – Defeat Ultra Greedier as Tainted ???
The Hierophant – Defeat Ultra Greedier as Tainted Bethany
The Lovers – Defeat Ultra Greedier as Tainted Magdalene
Repentance Achievements (Part 2)
The Chariot – Complete Hot Potato (challenge #42)
Justice – Complete Cantripped (challenge #43)
The Hermit – Complete Red Redemption (challenge #44)
Wheel of Fortune – Defeat Ultra Greedier as Tainted Cain
Strength – Defeat Ultra Greedier as Tainted Samson
The Hanged Man – Defeat Ultra Greedier as Tainted Keeper
Death – Defeat Ultra Greedier as Tainted Forgotten
Temperance – Complete DELETE THIS (challenge #45)
The Devil – Defeat Ultra Greedier as Tainted Azazel
The Tower – Defeat Ultra Greedier as Tainted Apollyon
The Stars – Defeat Ultra Greedier as Tainted Isaac
The Sun and the Moon – Defeat Ultra Greedier as Tainted Jacob
Judgement – Defeat Ultra Greedier as Tainted Lazarus
The World – Defeat Ultra Greedier as Tainted Eden
Old Capacitor – Kill 10 Battery Bums
Brimstone Bombs – After breaking Hornfel’s minecart, kill him before he can escape
Mega Mush – Earn all Hard mode completion marks for all non-tainted characters
Mom’s Lock – Defeat Isaac, ???, Satan and The Lamb as Tainted Isaac
Dice Bag – Defeat Mother as Tainted Isaac
Holy Crown – Defeat Isaac, ???, Satan and The Lamb as Tainted Magdalene
Mother’s Kiss – Defeat Mother as Tainted Magdalene
Glided Key – Defeat Isaac, ???, Satan and The Lamb as Tainted Cain
Lucky Sack – Defeat Mother as Tainted Cain
Your Soul – Defeat Isaac, ???, Satan and The Lamb as Tainted Judas
Number Magnet – Defeat Mother as Tainted Judas
Dingle Berry – Defeat Isaac, ???, Satan and The Lamb as Tainted ???
Ring Cap – Defeat Mother as Tainted ???
Strange Key – Defeat Isaac, ???, Satan and The Lamb as Tainted Eve
Lil Clot – Defeat Mother as Tainted Eve
Temporary Tattoo – Defeat Isaac, ???, Satan and The Lamb as Tainted Samson
Swallowed M80 – Defeat Mother as Tainted Samson
Wicked Crown – Defeat Isaac, ???, Satan and The Lamb as Tainted Azazel
Azazel’s Stump – Defeat Mother as Tainted Azazel
Torn Pocket – Defeat Isaac, ???, Satan and The Lamb as Tainted Lazarus
Torn Card – Defeat Mother as Tainted Lazarus
Nuh Uh! – Defeat Isaac, ???, Satan and The Lamb as Tainted Eden
Modeling Clay – Defeat Mother as Tainted Eden
Kid’s Drawing – Defeat Isaac, ???, Satan and The Lamb as Tainted Lost
Crystal Key – Defeat Mother as Tainted Lost
The Twins – Defeat Isaac, ???, Satan and The Lamb as Tainted Lilith
Adoption Papers – Defeat Mother as Tainted Lilith
Keeper’s Bargain – Defeat Isaac, ???, Satan and The Lamb as Tainted Keeper
Cursed Penny – Defeat Mother as Tainted Keeper
Cricket Leg – Defeat Isaac, ???, Satan and The Lamb as Tainted Apollyon
Apollyon’s Best Friend – Defeat Mother as Tainted Apollyon
Polished Bone – Defeat Isaac, ???, Satan and The Lamb as Tainted Forgotten
Hollow Heart – Defeat Mother as Tainted Forgotten
Expansion Pack – Defeat Isaac, ???, Satan and The Lamb as Tainted Bethany
Beth’s Essence – Defeat Mother as Tainted Bethany
RC Remote – Defeat Isaac, ???, Satan and The Lamb as Tainted Jacob
Found Soul – Defeat Mother as Tainted Jacob
Member Card – Spend 40+ coins in a single Shop
Golden Razor – In a single run, obtain 99 coins, then spend all the money.
Spindown Dice – Defeat Delirium as Tainted Isaac
Hypercoagulation – Defeat Delirium as Tainted Isaac
Bag of Crafting – Defeat Delirium as Tainted Cain
Dark Arts – Defeat Delirium as Tainted Judas
IBS – Defeat Delirium as Tainted ???
Sumptorium – Defeat Delirium as Tainted Eve
Berserk! – Defeat Delirium as Tainted Samson
Hemoptysis – Defeat Delirium as Tainted Azazel
Flip – Defeat Delirium as Tainted Lazarus
Corrupted Data – Defeat Delirium as Tainted Eden
Ghost Bombs – Defeat Delirium as Tainted Lost
Gello – Defeat Delirium as Tainted Lilith
Keeper’s Kin – Defeat Delirium as Tainted Keeper
Abyss – Defeat Delirium as Tainted Apollyon
Decap Attack – Defeat Delirium as Tainted Forgotten
Lemegeton – Defeat Delirium as Tainted Bethany
Anima Sola – Defeat Delirium as Tainted Jacob
Mega Chest – Defeat Mega Satan as Tainted Isaac
Queen of Hearts – Defeat Mega Satan as Tainted Magdalene
Gold Pill – Defeat Mega Satan as Tainted Cain
Black Sack – Defeat Mega Satan as Tainted Judas
Charming Poop – Defeat Mega Satan as Tainted ???
Horse Pill – Defeat Mega Satan as Tainted Eve
Crane Game – Defeat Mega Satan as Tainted Samson
Hell Game – Defeat Mega Satan as Tainted Azazel
Wooden Chest – Defeat Mega Satan as Tainted Lazarus
Wild Card – Defeat Mega Satan as Tainted Eden
Haunted Chest – Defeat Mega Satan as Tainted Lost
Fool’s Gold – Defeat Mega Satan as Tainted Lilith
Golden Penny – Defeat Mega Satan as Tainted Keeper
Rotten Beggar – Defeat Mega Satan as Tainted Apollyon
Golden Battery – Defeat Mega Satan as Tainted Forgotten
Confessional – Defeat Mega Satan as Tainted Bethany
Golden Trinket – Defeat Mega Satan as Tainted Jacob
Soul of Isaac – Defeat Hush and Boss Rush as Tainted Isaac
Soul of Magdalene – Defeat Hush and Boss Rush as Tainted Magdalene
Soul of Cain – Defeat Hush and Boss Rush as Tainted Cain
Soul of Judas – Defeat Hush and Boss Rush as Tainted Judas
Soul of ??? – Defeat Hush and Boss Rush as Tainted ???
Soul of Eve – Defeat Hush and Boss Rush as Tainted Eve
Soul of Samson – Defeat Hush and Boss Rush as Tainted Samson
Soul of Azazel – Defeat Hush and Boss Rush as Tainted Azazel
Soul of Lazarus – Defeat Hush and Boss Rush as Tainted Lazarus
Soul of Eden – Defeat Hush and Boss Rush as Tainted Eden
Soul of the Lost – Defeat Hush and Boss Rush as Tainted Lost
Soul of Lilith – Defeat Hush and Boss Rush as Tainted Lilith
Soul of the Keeper – Defeat Hush and Boss Rush as Tainted Keeper
Soul of Apollyon – Defeat Hush and Boss Rush as Tainted Apollyon
Soul of the Forgotten – Defeat Hush and Boss Rush as Tainted Forgotten
Soul of Bethany – Defeat Hush and Boss Rush as Tainted Bethany
Soul of Jacob & Esau – Defeat Hush and Boss Rush as Tainted Jacob
A Strange Door – Defeat Mother
Death Certificate – Earn all Hard mode completion marks for all characters, including tainted ones
Dead God – Unlock all the other achievements and collect every item in the game
Infinity
After getting the “Dead God” achievement on 3 save files, you get a special save file image.
There is also another image that appears at the starting screen when you get 3,000,000%.
